幽门螺杆菌的左氧氟沙星耐药性及其基因分析
Journal of Ningbo University(Natural Science & Engineering Edition)（2010）
Abstract
分析了宁波地区幽门螺杆菌(Helicobacter pylori,Hp)对左氧氟沙星的耐药情况,探讨了Hp对左氧氟沙星的耐药机制.取患者胃黏膜组织分离培养Hp,检测Hp对左氧氟沙星的耐药率;提取左氧氟沙星耐药Hp DNA,PCR扩增并测序比较.结果表明:宁波地区Hp对左氧氟沙星的耐药率为22.5%,左氧氟沙星耐药Hp菌株gyrA基因91位密码子发生点突变.提示宁波地区Hp对左氧氟沙星已产生一定的耐药性;左氧氟沙星耐药Hp gyrA基因突变可能是本地区左氧氟沙星耐药的重要原因之一.
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Key words
Helicobacter pylori,antibiotic resistance,levofloxacin,mutation
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