Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel
Bioorganic & Medicinal Chemistry Letters(2010)
摘要
A series of triarylethanolamine inhibitors of the Kv1.5 potassium channel have been prepared and evaluated for their effects in vitro and in vivo. The structure–activity relationship (SAR) studies described herein led to the development of potent, selective and orally active inhibitors of Kv1.5.
更多查看译文
关键词
Kv1.5,TAEA,Triarylethanolamine,Arrhythmia,Atrial fibrillation
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要