ChemInform Abstract: Complestatin to Chloropeptin I via a Quantitative Acid Catalyzed Rearrangement. Absolute Stereochemical Determination of Complestatin.

H. JAYASURIYA,G. M. SALITURO, S. K. SMITH,J. V. HECK,S. J. GOULD,S. B. SINGH,C. F. HOMNICK,M. K. HOLLOWAY,S. M. PITZENBERGER,M. A. PATANE

Cheminform（2010）

Cited 0|Views8

No score

Abstract

Complestatin and isomeric chloropeptin I are bicycle hexapeptides isolated from a Streptomyces sp. Both of these compounds are inhibitors of gp120-CD4 HIV fusion activity. In this paper, we describe an efficient acid catalyzed conversion of complestatin to chloropeptin I, provide a plausible mechanism for this transformation, and unambiguously assign the stereochemistry of complestatin. (C) 1998 Elsevier Science Ltd. All rights reserved.

Translated text

Key words

complestatin,stereochemical determination,catalyzed rearrangement,quantitative acid

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined