Influence of Neoadjuvant Chemotherapy on Expressions of ER,PR,pS2,C-erbB-2 and Ki-67 in Breast Cancer

Objective:To study the influence of neoadjuvant chemotherapy on expressions of ER、PR、pS2、C-erbB-2 and Ki-67 in breast cancer.Methods:Expressions of ER、PR、pS2、C-erbB-2、Ki-67 of 40 patients with breast cancer were measured by immunohistochemistry before and after neoadjuvant chemotherapy.Results:After neoadjuvant chemotherapy,the quantitative changes of ER,PR,pS2,C-erbB-2 and Ki-67 were 17.5%,15%,7.5%,22.5% and 32.5%,respectively.The changes of their status were 22.5%,42.5%,45%,12.5% and 50%,respectively.The difference of Ki-67 before and after primary chemotherapy was significant(t=3.218,P=0.003).Conclusion:The expressions of ER,PR,pS2,C-erbB-2,Ki-67 were influenced by neoadjuvant chemotherapy.Neoadjuvant chemotherapy could reduce Ki-67 expression significantly.