Potential Application of Quasi-Totipotent Embryonic Stem Cells: A 10-Year Study of Soft-Tissue Engineering with Embryonic Stem Cells

Based on our work in the past 10 years, we have concluded that mouse embryonic stem cells are "quasi-totipotent" in vitro; that is, they resemble and may even possess the full totipotency of germ cells, In this review, we discuss the data on the development of lymphoid tissues, skin, gut, and other tissues originating from embryonic stem cells in vitro. We explore the prospects of using mouse embryonic stem cells for tissue engineering.