Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy

Maikel Wijtmans,Dennis Verzijl, Cindy M.E. van Dam,Leontien Bosch, Martine J. Smit,Rob Leurs,Iwan J.P. de Esch

Bioorganic & Medicinal Chemistry Letters（2009）

引用 11|浏览12

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摘要

The strategic use of specific polycycloaliphatic groups in obtaining small antagonists for the CXCR3 receptor was investigated. 2-Adamantyl- and (iso)bornyl groups proved beneficial.

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关键词

CXCR3,Reductive amination,GPCR,Polycycloaliphatic

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