2009-2010年丙戊酸钠血药浓度监测数据分析
Pharmaceutical Journal of Chinese People's Liberation Army(2012)
Abstract
目的 探讨丙戊酸钠血药浓度监测及临床意义.方法 采用荧光偏振免疫分析法测定癫痫患者血清中丙戊酸浓度,并回顾性分析1220例次患者的血药浓度与临床疗效的相关性.结果 734( 60.16%)例次在有效浓度范围内,377(30.90%)例次小于有效浓度范围,109(8.94%)例次高于有效浓度范围;不同年龄段患者的血药浓度有效治疗范围无明显差异;给药剂量与血药浓度的相关性不稳定.结论 丙戊酸钠血药浓度个体差异大,因此在服药期间应适时监测血药浓度,并及时调整给药剂量,以提高临床疗效、降低不良反应.
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Key words
blood drug concentration,valproic acid sodium,clinical curative effect
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