Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors

Darrin W. Hopper,Matthew D. Vera,David How,Joshua Sabatini,Jason S. Xiang,Manus Ipek,Jennifer Thomason,Yonghan Hu,Eric Feyfant,Qin Wang,Katy E. Georgiadis,Erica Reifenberg,Richard T. Sheldon,Cristin C. Keohan,Manas K. Majumdar,Elisabeth A. Morris,Jerauld Skotnicki,Phaik-Eng Sum

Bioorganic & Medicinal Chemistry Letters（2009）

Cited 25|Views56

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Abstract

A subset of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides were identified as potent Agg-1, MMP-2 and MMP-13 inhibitors through the synthesis of a series of (Phenoxy)methyl biphenylsulfonamide carboxylates.

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Key words

Aggrecanase-1,Agg-1,ADAMTS-4,Biphenylsulfonamides,Osteoarthritis,OA,MMP-2,MMP-13

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