Processing and statistical analysis of laser Doppler data applied to the assessment of systemic anti-inflammatory drugs

Continuous laser Doppler measurements of methyl nicotinate-induced skin inflammation have been used to evaluate the activities of three oral non-steroidal anti-inflammatory drugs, indomethacin 50 mg (Indocid®), tiaprofenic acid 100 mg (Surgam) and sodium acetylsalicylate 1 g (Catalgine®). They were compared in a single-blind, randomized, intra-individual comparison (N = 16) versus placebo (lactose).