脑损伤患者血清肌酸激酶及乳酸脱氢酶同工酶的分析与临床应用
Journal of Southwest China Normal University(Natural Science Edition)(2008)
Abstract
为探讨肌酸激酶(CK)同工酶及乳酸脱氢酶(LDH)同工酶在脑损伤疾病诊断中的应用,使用日立7060全自动生化分析仪,酶偶联法检测肌酸激酶,速率法测乳酸脱氢酶,法国SEBIA全自动电泳仪琼脂糖凝胶电泳法测定79例脑损伤性疾病患者的肌酸激酶同工酶、乳酸脱氢酶及同工酶.研究发现:脑损伤后5天内,患者血清CK及LDH总活力显著升高(p<0.05);CK—MB、CK—BB随着病情的好转而降低直至恢复正常;LDH同工酶LDH_1、LDH_2、LDH_3、LDH_5在第一天和第二天有显著性变化,24h内LDH_1、LDH_2、LDH_3显著下降(p<0.05),LDH_5显著升高(p<0.05).血清CK及同工酶、LDH及其同工酶的测定对脑损伤患者的诊断和预后判断均有重要意义.
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Key words
severe head injury,creatine kinase,lactate dehydrogenase,isoenzyme
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