Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1.

Kumiko Takeuchi,William G Holloway,Jamie H McKinzie,Todd M Suter,Michael A Statnick,Peggy L Surface,Paul J Emmerson,Elizabeth M Thomas,Miles G Siegel,James E Matt,Chad N Wolfe,Charles H Mitch

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

A structurally unique and new class of opioid receptor antagonists (OpRAs) that bear no structural resemblance with morphine or endogenous opioid peptides has been discovered. A series of carboxamido-biaryl ethers were identified as potent receptor antagonists against mu, kappa, and delta opioid receptors.

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关键词

Opioid receptor antagonists (OpRAs),Carboxamido-biaryl ethers,Obesity

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