Virus-specific cytotoxic lymphocyte response in a neurotropic murine leukemia virus infection

NFS/N mice infected with neurotropic CasBrM murine leukemia virus (MuLV) at 21 days of age were resistant to neurologic disease and demonstrated MuLV-specific cytotoxic T lymphocyte (CTL) activity in spleen cells after in vitro stimulation. NFS/N mice infected with CasBrM MuLV at 2 days of age failed to generate a significant MuLV-specific CTL response and developed neurologic disease 5–8 weeks later. Protection from neurologic disease transferred with fewer in vitro stimulated immune spleen cells than immune T cells from NFS/N mice infected with CasBrM MuLV at 21 days of age. CasBrM MuLV-specific CTL may play an important role in resistance to the paralytic effects of CasBrM MuLV infection by affecting virus dissemination to the central nervous system.