2,3 '-Disubstituted-2-(2 '-Carboxycyclopropyl)Glycines As Potent And Selective Antagonists Of Metabotropic Glutamate Receptors
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(1998)
Abstract
2-(9-Xanthylmethyl)-2-(2' -carboxycyclopropyl) glycine 6e is a novel metabotropic glutamate receptor antagonist. A series of alpha, C-3' disubstituted (carboxycyclopropyl)glycines 6f-n were prepared. Antagonist activity was observed for all these compounds at group 2 and group 3 mGluRs. Although they were slightly less active on group 2 mGluRs than non C-3' substituted 6e, the compounds 6f-n were more selective with lesser or no activity on group I mGluR subtypes (IC50 values greater than 100 mu m). (C) 1998 Elsevier Science Ltd. All rights reserved.
MoreTranslated text
Key words
metabotropic glutamate receptor
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined