2011年四川省肿瘤医院细菌耐药性监测
Laboratory Medicine and Clinic(2013)
Abstract
目的了解2011年四川省肿瘤医院临床分离株对常用抗菌药物的耐药性。方法采用MIC法对1 582株临床分离株进行药敏试验。按美国临床实验室标准化协会2009版判读结果。结果 1 582株临床分离株中革兰阳性球菌占10.1%(160/1 582),革兰阴性杆菌占89.9%(1 422/1 582)。耐甲氧西林金黄色葡萄球菌(MR-SA)的检出率占金黄色葡萄球菌的26.1%。葡萄球菌中甲氧西林耐药株对β-内酰胺类抗菌药物和其他测试药的耐药率显著高于甲氧西林敏感株,未发现万古霉素和利奈唑胺耐药株。肠球菌属中屎肠球菌对多数测试药物的耐药率高于粪肠球菌,出现1株耐万古霉素菌株,无利奈唑胺耐药株。革兰阴性肠杆菌中,大肠埃希菌和克雷伯菌属产ESBLs株分别为66.5%和21.2%。产ESBLs菌株对大多β-内酰胺类抗菌药物高度耐药。亚安培南对肠杆菌科细菌抗菌活性最强。出现了较多的多重耐药鲍曼不动杆菌。结论该院细菌耐药性较2010年有增长趋势,尤其出现了耐万古霉素的肠球菌且多重耐药鲍曼不动杆菌显著增多,应引起注意,并及早采取防控措施。
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Key words
extended-spectrum beta-lactamases,gram negative bacilli,anti-bacterial agents,methicillin-resistant S.aureus,drug resistance,beta-lactamases,staphylococcus aureus,gram-positive bacteria,gram-negative bacteria,bacterial,antimicrobial agents,gram positive cocci,bacterial resistance
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