Use Of A Motor Load Analyzer To Monitor The Granulation Process In A High-Intensity Mixer

AbstractA motor load analyzer instrumented to a high intensity mixer was examined for its ability to monitor the granulation process with varying formulation and processing parameters. A lactose/microcrystalline cellulose blend with povidone as the binder was used as the test system.The motor load analyzer was able to note chopper operation and liquid addition methods. However, it could not differentiate between povidone addition as an aqueous solution or as part of the lactose microcrystalline cellulose blend, followed by massing with water. The compression characteristics of the granulations depended upon chopper usage, and povidone and liquid amounts, and their methods of addition.