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血清葡萄糖-6磷酸异构酶测定在幼年特发性关节炎中的临床意义

Journal of Clinical Pediatrics(2011)

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Abstract
目的 了解血清葡萄糖-6磷酸异构酶(G6PI)在多关节型和少关节型幼年特发性关节炎(polyarthritis and oligoarthritis JIA,pJIA and oJIA)及系统性红斑狼疮(SLE)患儿中的表达水平,以阐明其对pJIA和oJIA的诊断价值.方法 JIA组30例、SLE组19例和健康组37名.应用酶联免疫吸附试验(ELISA)测定三组儿童血清G6PI浓度,比较三组血清G6PI浓度、G6PI阳性率.结果 JIA组血清G6PI浓度为(0.15±0.11)μg/ml,SLE正组为(0.22±0.41)μg/ml,健康对照组为(0.17±0.28)μg/ml,三组比较差异无统计学意义(P>0.05).各组G6PI高浓度例数均为2例,各组间相比差异无统计学意义(P>0.05).结论 血清G6PI浓度测定不适用于辅助诊断关节病变为主的JIA.
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Key words
Juvenile idiopathic arthritis,diagnosis,glucose-6-phosphate isomerase
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