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Discovery of 4-Azaindoles As Novel Inhibitors of C-Met Kinase.

John Porter,Simon Lumb,Richard J. Franklin,Jose M. Gascon-Simorte,Mark Calmiano,Kelly Le Riche,Benedicte Lallemand,Jean Keyaerts,Helen Edwards,Alison Maloney,Jean Delgado,Lloyd King,Anne Foley,Fabien Lecomte,James Reuberson,Christoph Meier,Mark Batchelor

Bioorganic & Medicinal Chemistry Letters（2009）

Cited 47|Views15
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Abstract
A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development are discussed.
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Key words
c-Met Kinase inhibitor,Hepatocyte growth factor receptor inhibitor,Kinase inhibitor,Azaindole
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