Paracetamol: a haemorrhagic risk factor in patients on warfarin.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY(2005)
摘要
Aim To quantify the effect of paracetamol on the anticoagulant effect of warfarin under normal clinical conditions. Patients and methods In a prospective double-blind, cross-over, placebo-controlled study, 11 patients on stable warfarin therapy received in random order two 14-day regimens of paracetamol 4 g day(-1) or placebo, with a 14-day or more wash-out period in between, time necessary to fulfil the inclusion criteria. Results In patients on paracetamol, the mean maximum increase in the International Normalized Ratio (INR) observed was 1.04 +/- 0.55 vs. 0.20 +/- 0.32 in those on placebo (P = 0.003). The mean maximum INR observed was significantly higher with paracetamol than with placebo (3.47 vs. 2.61, P = 0.01). In patients receiving paracetamol, the mean observed INR was significantly increased after 4 days (+ 0.6 +/- 0.6, P < 0.001). Conclusion Paracetamol at 4 g day(-1) induces a significant increase in INR in patients receiving a stable regimen of warfarin, increasing the risk of bleeding associated with warfarin.
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关键词
anticoagulant,bleeding,INR,interaction,paracetamol,warfarin
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