Simultaneous Analysis Of The Vaca, Caga, And Icea Status Of Helicobacter Pylori By Multiplex Pcr And Reverse Hybridization.

Europe (Spain and Portugal, n=101), among the 53 type sl strains, 6 (11.3%) were sla and 47 (88.7%) were slb.Among 28 strains from Australia, 13 (72.2%) of 18 sl strains were sla and 5 (27.8%) were slb.In North America (n=50), 16 (50%) of the 32 type sl strains were sla and 16 (50%) were slb.In Central and South America (n=78), all of the 56 type sl strains were sla.In East Asia (n=63), 7 (11.1%)were sla, 3 (4.8%)were slb, and 53 (84.1%) were sic, a novel subtype which has not been observed in other parts of the world, except in patients originating from East Asia.Among the 302 type sl strains from Northern and Central Europe, North America, and Australia, the prevalence of ml (49.3%) and m2 (50.7%) was equal.However, among the 179 strains from Spain, Portugal, Central and South America, ml (83.5%) was more prevalent than m2 (16.5%) (P < 0.001).Conclusion.These data confirm the existence of distinct, well-conserved, genotypes of H. pylori, with characteristic geographic distribution.Such findings help explain regional differences in the relationship between H. pylori genotypes and clinical outcomes.