Discovery of adamantane ethers as inhibitors of 11β-HSD-1: Synthesis and biological evaluation

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

The synthesis and SAR of adamantane ethers are described as novel, potent and selective inhibitors of 11β-HSD-1. An X-ray crystal structure of one of these inhibitors bound to h-11β-HSD-1 is also described.

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关键词

Metabolic syndrome,11β-HSD-1,11β-HSD-2,Inhibitor,Adamantane ethers,X-ray crystal structure

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