GTP regulation of platelet-activating factor binding to human neutrophil membranes
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS（1986）
摘要
Radiolabeled ligand binding studies showed that specific receptors for platelet-activating factor are present in human neutrophil membranes. GTP at 10 −7 to 10 −3 M decreased the specific binding of platelet-activating factor to neutrophil membranes in a dose-dependent manner. Inhibition of platelet-activating factor binding was also induced by other guanine nucleotides but not by adenine nucleotides. Our results suggest that platelet-activating factor receptor in human neutrophil membranes may be coupled to a guanine nucleotide binding protein.
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关键词
gi,formyl-methionyl-leucyl-phenylalanine,adenosine-3′-5′-cyclic monophosphate,gdp-β-s,cgmp,paf,guanine nucleotide binding protein,the inhibitory g protein associated with adenylate cyclase,g protein,gtp-γ-s,camp,gs,guanosine-5′-o-(3-thiotriphosphate),5′-guanylylimidodiphosphate,guanosine-3′-5′-cyclic monophosphate,fmlp,the stimulatory g protein associated with adenylate cyclsae,guanosine-5′-o-(2-thiodiphosphate),platelet-activating factor (1-o-alkyl-2-o-acetyl-sn-glyceryl-3-phosphorylcholine),gppnhp
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