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Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase

Gretchen M. Schroeder,Xiao-Tao Chen,David K. Williams,David S. Nirschl,Zhen-Wei Cai,Donna Wei,John S. Tokarski,Yongmi An,John Sack,Zhong Chen,Tram Huynh,Wayne Vaccaro,Michael Poss,Barri Wautlet,Johnni Gullo-Brown,Kristen Kellar,Veeraswamy Manne,John T. Hunt,Tai W. Wong,Louis J. Lombardo,Joseph Fargnoli,Robert M. Borzilleri

Bioorganic & Medicinal Chemistry Letters（2008）

Cited 66|Views78
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Abstract
A variety of pyrrolo[2,1-f][1,2,4]triazines were synthesized and evaluated as Met kinase inhibitors. Substitution at the pyrrolotriazine C-5 or C-6 position gave compounds with potent activity in the Met-driven GTL-16 human gastric carcinoma cell line.
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Key words
Met kinase,Hepatocyte growth factor receptor,HGFR,Pyrrolotriazine,Gastric carcinoma
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