THE ROLE OF IL-4, IL-8, IL-10 IN ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Objective:The research aims at studying the role of peripheral blood interleukin 4(IL-4),interleukin 8(IL-8) and interleukin 10(IL-10) in asthma and chronic obstructive pulmonary disease(COPD).Methods: Use double-antibody sandwich enzyme-linked immunosorbent assam(ELISA) to detect the content of serum IL-4,IL-8 and IL-10 in 50 cases of acute exacerbation of COPD(AECOPD),50 cases of paracmastic COPD,50 cases of acute asthma,50 cases of paracmastic asthma and 50 cases of healthy volunteers(healthy control group).Results: The levels of IL-4 and IL-8 in the serum of the patients with acute asthma were significantly higher than that of the paracmastic asthma group(P0.01),while the levels of serum IL-4、IL-8 in these two groups were significantly higher than that in the healthy group(P0.01).The levels of IL-10 in the serum of the acute asthma group was significantly lower than that in the paracmastic asthma group(P0.01),while the level of serum IL-10 in both groups were significantly lower than that in the healthy group(P0.01).The levels of IL-4 and IL-8 in the serum of the patients with AECOPD was significantly higher than that in the paracmastic COPD group(P0.01),while the levels of serum IL-4 and IL-8 in the two groups were significantly higher than that in the healthy group(P 0.01).the IL-10 level in the serum of the patients with AECOPD was significantly lower than that of the paracmastic COPD group(P0.01) and the levels of serum IL-10 in both groups were singnificantly lower than in the healthy group(P0.01).The serum IL-4 level in the acute asthma group was significantly higher than in the acute asthma group(P 0.01);the serum IL-8 level in AECOPD was significantly higher than in the acute asthma group(P 0.01);the level of serum IL-10 in the acute asthma group asthma was significantly lower than in AECOPD group(P 0.01).Conclusions: IL-4,IL-8 and IL-10 are engaged in asthma and COPD airway inflammatory response.IL-4 and IL-8 are inflammation-promoting factors and IL-10 is inhibitory inflammatory factor.IL-4 plays an important role in asthma's airway inflammation and IL-8,IL-10 are main inflammatory factors in COPD.