Natural history of preclinical IDDM in high risk siblings

Mikael Knip,P Vahasalo,Jukka K Karjalainen,R Lounamaa,H K Akerblom, J Tuomilehto,Liisa Toivanen,E Virtala,Janne Pitkaniemi, Annette Fagerlund,M V Flittner,Bengt Gustafsson, C Haggquist,A Hakulinen,L Herva, Paivi H Hiltunen,T Huhtamaki,N P Huttunen,T Huupponen, M Hyttinen,Tatsuhiro Joki,R Jokisalo,M L Kaar,Suvi P Kallio,Eero A Kaprio,U Kaski, Larissa Laine,Janne H Lappalainen,Jorma Maenpaa, A L Makela,Kirstimaria Niemi,Aila Niiranen,A Nuuja,P Ojajarvi,Timo Otonkoski,Kalevi K Pihlajamaki,S Pontynen,Jukka Rajantie,Juhani Sankala, Jessica R Schumacher,Mikko J Sillanpaa, M R Stahlberg,C H Strahlmann,Taru Uotila,M Vare,P Varimo, G Wetterstrand,A Aro, Helena Hurme, H Hoyty,Jorma Ilonen,P Leinikki,Aaro Miettinen,L Rasanen,A Reunanen,Erkki Savilahti,E Tuomilehtowolf,Suvi M Virtanen

Diabetologia（1994）

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Abstract

Summary To learn more about the preclinical phase of IDDM we observed for a median period of 46.5 months (range 0.5–69 months) a group of 57 siblings positive for ICA and/or IAA when first screened within 6 months of the diagnosis of the proband. Sequential blood samples and IVGTTs were obtained at intervals of 6–12 months. Seventeen siblings (29.8%) presented with IDDM during the observation period. The duration of the known preclinical period ranged from 0.5 to 51 months (median 29 months). The converters were younger than the other siblings (PPPPPPPPP

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Key words

preclinical iddm,early insulin response,glucose elimination rate.,islet cell antibodies,natural history

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