Zinc Metal-Promoted Cross-Coupling Reaction of Non-Activated Alkyl Halides with Aldehydes in the Presence of Chlorotrimethylsilane

Takatoshi Ito,Yoshio Ishino,Takumi Mizuno,Akira Ishikawa, Jun-ichi Kobayashi

SYNLETT（2003）

引用 16|浏览2

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摘要

Treatment of non-activated alkyl halides 1 with aldehydes 3 in the presence of zinc metal and chlorotrimethylsilane (TMSCl), DMA and/or NMP in THF brought about highly facile and effective cross-coupling to give the corresponding alcohols in good yield. These reactions are assumed to proceed through zinc reagent intermediates generated in situ.

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关键词

addition reactions,non-activated alkyl halides,zinc,TMSCl,aldehydes

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