Role of gaseous signal molecules in the development of hepatic cirrhosis with portal hypertension

Nitrogen monoxide,carbon monoxide and hydrogen sulfide are three types of endogenous gas molecules that are able to exert diverse biological effects.As they can dilate blood vessels and suppress platelet aggregation and cell multiplication,the research on these gas signal molecules has become active.Their role in the development of hepatic cirrhosis with portal hypertension has gradually attracted more attention.Here,we will review the role of these gas signal molecules in the development of hepatic cirrhosis with portal hypertension.