Effect of "Yiqi Wenyang Decoction" on cardiac function and content of ATP in rats with heart failure after myocardial infarction

Objective To observe the effect of Yiqi Decoction on cardiac function and content of ATP in rats with heart failure after myocardial infarction.Methods Anterior descending branch of coronary artery was ligated to establish the rat models.After 2 weeks,the rats were divided into 6 groups: model group,sham-operation group,Trimetazidine group(TMZ group) and Yiqi Wenyang groups(large,medium and small dose),10 rats in each group,and intervened for 8 weeks.The BNP level was determined by ELISA,Hemodynamic changes such as HR,LVSP,LVEDP and(±LVdp/dtmax) were detected,and the contents of AMP,ADP and ATP were measured by HPLC.Results For the cardiac function,compared with model group after treatment,the LVSP and +LVdp/dtmax were increased in sham-operation group,TMZ group,large dosage and medium dosage of Yiqi Wenyang groups(P0.05,P0.01),while the LVEDP,-LVdp/dtmax and BNP were decreased(P0.05,P0.01);compared with the sham-operation group,the LVSP and +LVdp/dtmax were reduced in TMZ group,medium dosage and small dosage of Yiqi Wenyang groups(P0.05,P0.01);while the LVEDP,-LVdp/dtmax and BNP were increased(P0.01);compared with TMZ group,the +LVdp/dtmax was reduced in medium dosage and small dosage of Yiqi Wenyang groups(P0.05,P0.01),while the LVEDP and-LVdp/dtmax were increased(P0.01),the BNP in small dosage of Yiqi Wenyang group was increased(P0.01);compared with large dosage of Yiqi Wenyang group,the LVSP and +LVdp/dtmax in medium and small dosage of Yiqi Wenyang groups were reduced(P0.05,P0.01),while the LVEDP and-LVdp/dtmax were increased(P0.01),the BNP in small dosage of Yiqi Wenyang group was increased(P0.01).For energy metabolism,compared with model group,the AMP and ADP were increased in sham-operation group,TMZ group,medium and large dosage of Yiqi Wenyang groups(P0.05,P0.01),the ATP was decreased(P0.05,P0.01);compared with the sham-operation group,the ADP was increased in three Yiqi Wenyang groups(P0.05,P0.01),while the ATP was decreased(P0.01);compared with TMZ group,the ADP in medium and small dosage of Yiqi Wenyang groups was increased(P0.05,P0.01),and the ATP was decreased(P0.01),without significant difference from large dose of Yiqi Wenyang group(P0.05);compared with large dosage of Yiqi Wenyang group,the ATP in small dosage group was decreased(P0.01).Conclusion Yiqi Decoction can improve the cardiac function in rats with heart failure and optimize the energy metabolism of the myocardical cells.