A nonacid degradable linker for solid-phase synthesis.
ORGANIC LETTERS(2007)
摘要
Synthesis and applications of two new nonacid degradable linkers as an alternative to the Wang linker for solid-phase synthesis are described. Resin from linker 2 looks superior to linker 1 in terms of yields for both anchoring of the first building block and cleavage and in terms of higher purity of the final product. Use of linker 2 avoids side reactions associated with the use of Wang resin due to an undesired cleavage during final acid treatment.
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关键词
nonacid degradable linker,synthesis,solid-phase
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