Value of 99 Tc-MDP Combining with 89 Sr in Therapy of Osseous Metastasis in Patients with Tumor

Objective To investigate the therapeutic efficacy of 99Tc-MDP combining with 89Sr in alleviating pain of patients with osseous metastasis.Methods 89Sr 3mci was intravenously injected into 120 patients with osseous metastasis,after a week,99Tc-MDP,22mg/d,was intravenously injected for 10 days.One course of treatment was one month and was carried on 3 to 6 months;89Sr was used in every 3 to 4 months,three times at most.Results The pain was significant relieved in 107 patients,relieved in 8 patients,and inefficient in 5 patients.The effective power was 96%(relieve in 2 or 3 weeks);The time extended more than a year and a half.Myelosuppression was occured in few patient;Some patients with destruction of bone were obviously recovered.Conclusion There are conspicuous effect of 99Tc-MDP combining with 89Sr in therapying patients with osseous metastasis and conspicuous recovery for destruction of bone induced by osseous metastasis;Patients with osseous metastasis should be treated with 99Tc-MDP combining with 89Sr at an early date.