Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands—Part II

Simon E. Ward,Peter Eddershaw,Sean T. Flynn,Laurie Gordon,Peter J. Lovell,Susan H. Moore,Claire M. Scott,Paul W. Smith,Kevin M. Thewlis,Paul A. Wyman

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

SAR studies on a series of substituted phenyl piperazines and piperidines are described. Several examples are disclosed as potent 5-HT1 receptor ligands and their PK profiles presented.

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关键词

5-HT1,SSRI,Serotonin,5-HT1A antagonist,Depression

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