Synthesis of novel N 2 -adamantyl derivatives of 2-amino-6-methyl-4(3H)-pyrimidinone as potential activators of tumor necrosis factor (TNF) release

I. A. Novakov,B. S. Orlinson,R. V. Brunilin,M. B. Nawrozkij,E. N. Savel’ev, G. A. Novikova

Chemistry of Heterocyclic Compounds（2006）

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摘要

A method has been developed for the synthesis of N 2 -adamantyl-2-amino-6-methyl-4(3H)-pyrimidinones based on the reaction of (adamant-1-yl)alkylamine with 2-(ethylsulfanyl)-6-methyl-4(3H)-pyrimidinone which can lead to the corresponding derivatives in which the exocyclic nitrogen atom and the adamantyl radical are separated by a hydrocarbon fragment.

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关键词

(adamant-1-yl)alkylamines,2-(adamant-1-yl)alkylamino-6-methyl-4(3H)-pyrimidinones,2-(ethylsulfanyl)-6-methyl-4(3H)-pyrimidinone,aminolysis

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