Analysis of Distribution,Resistance and Its Production of Metal Enzyme of Acinetobacter Baumannii Specimen in Neurosurgery Department

Objective To understand the specimens distribution,resistance and its metal beta-lactamase(MBLs) production of acinetobacter baumannii(ABA) in neurosurgery department.Methods Four hundred and fifty-nine strains of Neurosurgery separated ABA from Guanlan People's Hospital from Jan.2010 to Jun.2012 were tested with the VITEK 2 compact automated microbial analysis system to detect the antibiotic susceptibility spectrum to 18 antibiotics,and the MBLs production was tested by double disk synergy.Results The ABA sputum specimen constitution ratio of the neurosurgery department was 88.02%(404 /459);serious resistance to AMP,CZO,FTN and CTT was observed with the resistance rates all over 85%;151 strains producing MBLs among the 256 strains with multi-drug-resistance resistant to imipenem(IPM) were screened out forming a production rate of 59.0%(151 /256),32.9% of the total detected number of strains(151/459);MBLs strains have serious drug resistance,with total resistance to seven kinds of antibiotics observed,and over 80% resistance to another 10 kinds of antibiotics;the MBLs strain and non-MBLs strain resistance rate comparison: except CZO,FTN,CTT,the differences of the remaining 15 kinds of antibiotics were all statistically significant(P 0.01).Conclusion ABA is mainly isolated from sputum in neurosurgery department,the drug resistance of which is serious;understanding the specimens distribution,resistance and its MBLs production is of great significance for curing ABA caused infection and controlling the spread of MBLs strains.