成骨生长肽促成骨作用的研究进展

Journal of Shanghai Jiaotong University(Medical Science)(2010)

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Abstract
成骨生长肽(OGP)具有促成骨作用,具有较大的潜在临床应用价值,是国内外研究的热点。动物体内实验和体外细胞实验表明,OGP能促进骨密度增加,加速骨折愈合,促进体外培养大鼠成骨细胞的成骨功能,增加核心结合因子α1、Ⅰ型胶原mRNA表达水平,促进骨髓间充质干细胞的增殖和分化,上调成骨标志物的表达。文章对OGP促成骨作用的研究进展进行综述。
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Key words
osteogenesis,bone marrow mesenchymal stem cells,osteogenic growth peptide
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