Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa

Bioorganic & Medicinal Chemistry（2007）

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摘要

A series of thiophene-anthranilamide fXa inhibitors is reported having subnanomolar inhibitory potency. The pharmacokinetic profile of compound 31 was evaluated in dogs. The X-ray crystal structure of this compound bound to factor Xa provides insight into the observed SAR for binding to factor Xa.

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关键词

Factor Xa inhibitor,Anticoagulant,Non-amidine,Thrombosis

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