Substitution therapy with recombinant growth hormone (somatrem) in adults with growth hormone deficiency.

The effects of a 12-week period of substitution therapy with somatrem have been investigated in six adults with confirmed hGH deficiency. Five of the six patients experienced a subjective improvement, mentally and physically, but these improvements were not demonstrated when the patients were assessed objectively. No side-effects were reported. Serum procollagen III peptide increased in all patients and serum IGF-1 increased in five of the six patients.