Fibrinolytic response after injection of desamino-d-arginine vasopressin (dDAVP) in healthy volunteers

The fibrinolytic response to desmopressin (dDAVP) given intravenously (i.v.) at 24-h intervals for 4 days and once subcutaneously (s.c.) 1 week later was studied in 6 healthy volunteers. The plasma levels of the tissue plasminogen activator (t-PA) activity were increased 10- to 20-fold and the t-PA antigen 2- to 3-fold, compared to the levels before i.v. injection. The PAI-1 concentration decreased after each i.v. injection and also following the s.c. injection.