Using Sulfamic Acid as a Catalyst for the Multi-component Coupling Synthesis of β-Acetamido Ketones

An efficient and improved procedure for the synthesis of β-acetylamino ketones is developed using sulfamic acid as a reusable,green catalyst at room temperature. In particular,bi-functional groups β-acetylamino ketones were first synthesized from acetyl chloride,acetonitrile,acetophenone and isophthalic aldehyde within our present learning. In this system,the catalyst is disclosed as inexpensive,recoverable and recyclable for the synthesis of β-acetamido ketones.