Replication of Scrapie Strains in Vitro and Their Influence on Neuronal Functions.: SCRAPIE STRAIN REPLICATION

Annals of the New York Academy of SciencesVolume 724, Issue 1 p. 331-337 Replication of Scrapie Strains in Vitro and Their Influence on Neuronal Functions SCRAPIE STRAIN REPLICATION RICHARD RUBENSTEIN, RICHARD RUBENSTEIN Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorDENG HUI, DENG HUI Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorRICHARD RACE, RICHARD RACE Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorWEINA JU, WEINA JU Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorCAROL SCALICI, CAROL SCALICI Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorMICHAEL PAPINI, MICHAEL PAPINI Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorRICHARD KASCSAK, RICHARD KASCSAK Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorRICHARD CARP, RICHARD CARP Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this author RICHARD RUBENSTEIN, RICHARD RUBENSTEIN Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorDENG HUI, DENG HUI Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorRICHARD RACE, RICHARD RACE Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorWEINA JU, WEINA JU Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorCAROL SCALICI, CAROL SCALICI Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorMICHAEL PAPINI, MICHAEL PAPINI Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorRICHARD KASCSAK, RICHARD KASCSAK Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this authorRICHARD CARP, RICHARD CARP Institute for Basic Research in Developmental Disabilities New York State Office of Mental Retardation and Developmental Disabilities 1050 Forest Hill Road Staten Island, New York 10314Search for more papers by this author First published: May 1994 https://doi.org/10.1111/j.1749-6632.1994.tb38924.xCitations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Kascask, R. J., R. Rubenstein & R. I. Carp. 1991. Evidence for biological and structural diversity among scrapie strains. Curr. Top. Microbiol. Immunol. 172: 139–152. 2 Carp, R. I. & R. Rubenstein. 1991. Diversity and significance of scrapie strains. Sem. Virol. 2: 825–831. 3 Dickinson, A. G. 1976. Scrapie in sheep and goats. In Slow Virus Diseases of Animals and Man. R. H. Kimberlin, Ed. 209–241. Amsterdam : North-Holland. 4 Kimberlin, R. H., S. Cole & C. A. Walker. 1987. Temporary and permanent modifications to a single strain of mouse scrapie on transmission to rats and hamsters. J. Gen. Virol. 68: 1875–1881. 5 Buyukmihci, N., M. Rorvik & R. F. Marsh. 1980. Replication of the scrapie agent in ocular neural tissues. Proc. Natl. Acad. Sci. USA 77: 1169–1171. 6 Buyukmihci, N., F. Goehring-Harmon & R. F. Marsh. 1983. 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Alterations in neurotransmitter-related enzyme activity in scrapie-infected PC12 cells. J. Gen. Viol. 72: 1279–1285. 18 Rubenstein, R., H. Deng, R. E. Race, W. Ju, C. L. Scalici, M. C. Papini, R. J. Kascsak & R. I. Carp. 1992. Demonstration of scrapie strain diversity in infected PC12 cells. J. Gen. Virol. 73: 3027–3031. 19 Clarke, M. C. & D. A. Haig. 1970a. Evidence for the multiplication of scrapie agent in cell culture. Nature 225: 100–101. 20 Clarke, M. C. & D. A. Haig. 1970b. Multiplication of scrapie agent in cell culture. Res. Vet. Sci. 11: 500–501. 21 Race, R. E., L. H. Fadness & B. Chesebro. 1987. Characterization of scrapie infection in mouse neuroblastoma cells. J. Gen. Virol. 68: 1391–1399. 22 Clarke, M. C. & G. C. Millson. 1976. Infection of a cell line of mouse L fibroblasts with scrapie agent. Nature 261: 144–145. 23 Butler, D. A., M. R. D. Scott, J. M. Bockman, D. R. Borchelt, A. Taraboulos, K. K. Hsiao, D. T. Kingsbury & S. B. Prusiner. 1988. Scrapie-induced murine neuroblastoma cells produce protease-resistant prion proteins. J. Virol. 62: 1558–1564. 24 Traynor, A. E., D. Schubert & W. E. Allen. 1982. Alterations of lipid metabolism in response to nerve growth factor. J. Neurochem. 39: 1677–1683. 25 Koreh, K. & M. E. Monaco. 1986. The relationship of hormone-sensitive and hormone-insensitive phosphatidylinositol to phosphatidylinositol 4,5-bisphosphate in the WRK-1 Cell. J. Biol. Chem. 261: 88–91. Citing Literature Volume724, Issue1Slow Infections of the Central Nervous System: The Legacy of Dr. Björn SigurdssonMay 1994Pages 331-337 ReferencesRelatedInformation