In vivo protection against chagasic cardiomyopathy progression using trypanocidal fractions from Lippia alba (Verbenaceae) essential oils

John Jaime Quimbaya Ramírez,Clara Isabel González Rugeles,Elena E. Stashenko,Julio Cesar Mantilla Hernández,Martha Lucía Díaz Galvis,Liliana Torcoroma García Sánchez

Industrial Crops and Products（2021）

引用 5|浏览11

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摘要

•A successfully model of chronic Chagas disease was induced in rats.•An oral therapy was developed from fractions of Lippia alba essential oils.•Echocardiographycal and histopathological test confirmed a cardioprotective effect.•The therapy showed a trypanocidal action similar to Benznidazole by qPCR analysis.•The treatment scheme was apparently non-toxic by clinical and pathological test.

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BenzLim,BNZ,CCC,ChD,Ct,d.a.i,DM,DNA,EOs,GC–MS,GPx,GRAS,GSH,IFN,IL,IVC,ML,MnSOD,MAHD,NFX,NF-κB,NYHA,OxiLim,PBS,PBSG,qPCR,q.s.p,ROS,SD,SOD,Th1,Th2,TNF,WHO

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