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Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: Synthesis and biological activity

Zixia Feng,Mark R. Hellberg,Najam A. Sharif,Marsha A. McLaughlin,Gary W. Williams,Daniel Scott, Tony Wallace

Bioorganic & Medicinal Chemistry（2009）

Cited 12|Views11
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Abstract
Novel 13-oxa prostaglandin analogs were designed, synthesized and evaluated for their antiglaucoma activities. AL-16082 was the most potent prostaglandin FP agonist in vitro (EC50=1.9nM). Its pro-drug AL-16049 significantly lowered intraocular pressure in the ocular hypertensive monkey eyes by 30% with low side-effects.
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Key words
Glaucoma,13-Oxa prostaglandin,Intraocular pressure (IOP)
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