PROSPECTIVE EVALUATION OF GENETIC ABNORMALITIES AND TELOMERASE EXPRESSION IN EXFOLIATED URINARY CELLS FOR BLADDER CANCER DETECTION

The Journal of Urology(2002)

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Abstract
Conclusions Urinary LOH analysis was the most sensitive and specific method for bladder cancer detection and it appeared less dependent on urine sediment quality. The logistic regression score may be an interesting complement to cystoscopy. The specificity of hTERT mRNA detection was incomplete since false-positives were observed in 31% of cases. Absent microsatellite instability in our cohort showed that these genomic alterations are not present at the early step of bladder cancer.
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Key words
bladder,bladder,neoplasms,microsatellite repeats,telomerase,loss of heterozygosity
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