Age-Related Increase Of Pulse Pressure And Plasminogen Activator Inhibitor-1 I/D Gene Polymorphism In Essential Hypertension

Background. Pulse pressure (PP). a marker of cyclic strain on the arterial wall. is a significant predictor of cardiovascular (CV) risk, particularly regarding the incidence of coronary arterial stenosis. Genes related to haemostatic and/or fibrinolytic factors are consistently influenced in vitro by mechanical strain.Background. Pulse pressure (PP). a marker of cyclic strain on the arterial wall. is a significant predictor of cardiovascular (CV) risk, particularly regarding the incidence of coronary arterial stenosis. Genes related to haemostatic and/or fibrinolytic factors are consistently influenced in vitro by mechanical strain. between age and PP in subjects with never treated essential hypertension.Results. In the studied population, the genotype deletion (D)/D at position -675 of the PAI-1 insertion (I)/D gene polymorphism was associated with a significant increase in the adjusted slope of the curve relating age to PP by comparison with the two other genotypes. No comparable difference in age-related changes in systolic, diastolic or mean blood pressure was foundConclusion. In subjects with essential hypertension, the PAI-1 I/D gene polymorphism modulates the age-mediated increase of PP, suggesting new insights on the complex interactions between genes, mechanical factors and CV risk.