The History Of Pertussis Vaccination: From Whole-Cell To Subunit Vaccines

A review of all studies and trials cannot be made in this context, but two sources are recommended, i.e., Whooping cough by Joseph E. Lapin [1] and a review by Fine and Clarkson [2]. In the early years of the twentieth century, attempts were made to develop whole-cell vaccines, but for these early studies, the current definition of vaccination may not be valid since many workers have considered prophylaxis to include preventive treatment in the incubation period of the disease, as noted by Lapin.