2-C-methyluridine modified hammerhead ribozyme against the estrogen receptor.
Bioorganic & Medicinal Chemistry Letters(2010)
摘要
A new synthesis of 2′-C-methyluridine phosphoramidite is presented. Special emphasis is dedicated to the improvement of the protection of the tertiary 2′-hydroxyl group. Comparison to previous protecting strategies and analysis of stability under 5′-DMTr removing conditions are discussed. The synthetic incorporation of this modified nucleoside into the catalytic core of a hammerhead ribozyme against the estrogen receptor α protein (ER-α), and transfection experiments in MCF-7 cell line are also presented.
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关键词
2′-C-methyluridine,Modified ribozyme,Estrogen receptor alpha
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