Preparation and the Efficacy Evaluation of an Oil-emulsion Inactivated Vaccine Against Novel Duck Reovirus Disease

Novel Duck Reovirus(NDRV) was the pathogen of duck Hemorrhagic-necrotic hepatitis,which was an epizootic disease of ducklings,has been prevailed in China since 2005.In order to control the disease,one oil-emulsion inactivated vaccine had been developed by NDRV JM85 and the potential protective efficacy was assessed.The study indicated that this vaccine could induce strong immune responses after secondary immunization of sheldrake and the titers of neutralizing antibodies reach the peak at 28d post-immunization.84d post-immunization,the neutralizing antibodies still maintain at a high level.Baby Muscovy ducks born from mothers vaccinated with the oil-emulsion vaccine were protected successfully against NDRV infection,during the first week of life when the risk of this disease was highest.These results showed that the vaccine had a good prospect for against novel duck reovirus disease.