Neuromuscular transmission in the murine mutants “motor end-plate disease” and “jolting”
Journal of the Neurological Sciences(1986)
Abstract
Mice with the inherited disorder “motor end-plate disease” suffered from a progressive neuromuscular weakness and muscular wasting. The weakness resulted from a failure of evoked transmitter release from the motor nerve terminals. The failure in transmission was all-or-nothing in nature. The numbers of muscle fibres in skeletal muscle and myelinated axons in several major nerve trunks were no different from normal. The loss in muscle bulk was caused by the neuromuscular defect and not from a loss of motor units or muscle fibres.
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Key words
Jolting,Motor end-plate disease,Mouse,Neuromuscular transmission
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