A rat model of spontaneously arrested hydrocephalus A behavioural study

HTX rats with congenital hydrocephalus that survived for more than 2 months are termed spontaneously arrested hydrocephalic rats. These rats showed impairment in learning, a reverse light–dark discrimination task in a Y-maze. A clear relationship between learning impairment and ventricular dilatation was observed in spontaneously arrested hydrocephalic animals. The usefulness and limitations of HTX-rats as an animal model of spontaneously arrested hydrocephalus are discussed.