Identification of two novel variants in PRKAG2 gene in Tunisian type 2 diabetic patients with family history of cardiovascular disease.

S Nouira,I Arfa,I Kammoun,A Abid,H Ouragini,I Dorboz,W Ghazouani,S Ben Fadhel,M M Zorgati,S Ben Ammar,S Blousa-Chabchoub,S Kachboura,S Abdelhak

Diabetes Research and Clinical Practice（2010）

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摘要

We report the identification of two novel polymorphisms in the PRKAG2 gene and preliminary association study between 5′-UTR and exon 1 polymorphisms with susceptibility to type 2 diabetes. No association with type 2 diabetes was identified. However, one of these newly identified polymorphisms (p.Ser20Ile) is likely associated with cardiac disease.

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关键词

5′-AMP-activated protein kinase (AMPK),SNP,Type 2 diabetes,Cardiac failure

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