Effect of Wenbu Shenyang prescription on blood hemodynamics,content of cardiac troponin I and brain natriuretic peptide in rats with heart failure after myocardial infarction

[Objective] To observe the effect of Wenbu Shengyang(warming kidney Yang) prescription on cardiac hemodynamics,the content of cardiac troponin I(TNI) and brain natriuretic peptide(BNP) in rats with heart failure after myocardial infarction.[Methods] The heart failure was established in rats by ligating left anterial descending coronary artery.Rats were divided into model group,trimetazidinetriazine control group,sham operation normal control group,high,middle and low doses of warming kidney Yang prescription group randomly.After treatment for 8 weeks,we measured the hemodynamics including left ventricular systolic pressure(LVSP),left ventricular diastolic pressure(LVDP),the increased or decreased maximum rate of left ventricular pressure(±LVdp/dtmax).The level of TNI was determined through sandwich ELISA before and after medicine intervention in myocardical tissue.The content of BNP was determined by ELISA before and after treatment.[Results] Compared with model group,warming kindey Yang prescription with middle and high dosage and trimetazidinetriazine control group could obviously increase LVSP,+LVdp/dt(P0.01) and decrease LVEDP,-LV dp/dt(P0.01).The effect of high doses was better than middle doses.Compared with the model group,every doses of warming kidney Yang and trimetazidine could significantly lower the levels of TNI and BNP(P0.01).[Conclusion] Warming kidney Yang prescription can significantly improve cardiac systolic and diastolic function of rats with heart failure as well as reduce myocardial damage and improve heart function.