LL-Z1271α: An Interleukin-1β Production Inhibitor

LL-Z1271α, a fungal metabolite, dose-dependently inhibited interleukin-1β (IL-1β) production in lipopolysaccharide (LPS)-stimulated human whole blood. Oral administration of LL-Z1271α to LPS-challenged mice caused significant lowering in the IL-1β levels in peritoneal cavity. Data presented suggest that LL-Z1271α inhibits IL-1β production by a novel mechanism as the inhibitory activity was not due to effects on caspase-1 (IL-1β converting enzyme), the ATP-induced release mechanism or a lysosomotrophic effect.